Description:
Sclavo PT-ReadyQuick is of rabbit brain origin but resembles human BCT in its low International Sensitivity Index (ISI). The ISI of Sclavo PT-ReadyQuick is < 1.1 (using manual calibration techniques) and is calibrated against the WHO international reference preparation . Sclavo PT-ReadyQuick is particularly suited to the monitoring of oral anticoagulant therapy and, in conjunction with the appropriate factor deficient plasma, the measurement of factor activity in the extrinsic pathway. Tissue thromboplastin, in the presence of calcium ions, is an activator which initiates the extrinsic pathway of coagulation. When a mixture of tissue thromboplastin and calcium ions is added to normal citrated plasma, the clotting mechanism is activated, leading to a fibrin clot. If a deficiency exists within the extrinsic pathway, the time required for clot formation will be prolonged depending on the severity of the deficiency.
