Description:
LDH-P is an enzyme which catalyzes the reduction of pyruvic acid to lactic acid. The wide-spread diffusion of LDH in the organism explains why this enzyme increases in the serum in numerous pathological conditions involving various different tissues, such as the liver (viral hepatitis), cardiac muscle(myocardial infarction), skeletal muscle and kidneys. The kidney is the organ containing the highest concentration of the enzyme, followed by the myocardium, skeletal muscle,spleen, liver and lungs. LDH activity in the serum is determined by a group of five isoenzymes deriving fromdifferent tissues. LDH activity can be determined bymeasuring the conversion oflactate to pyruvate or pyruvate to lactate.
